(hypoxia) or inflammation can cause cells to retain iron. The result is hereditary hyperferritinemia cataract syndrome (hhcs an inherited condition of early-onset cataracts which could be dangerously confused with hemochromatosis (iron overload) unless a person is diagnosed using the full iron panel : Hemoglobin : the iron-containing protein in the blood that carries iron. Transferrin-iron saturation percentage (TS) : a measure of iron carried by the protein transferrin in the serum; represented by fasting serum iron divided by total iron binding capacity (tibc multiplied by 100. Normally the RPE has ways to prevent iron from entering the retina when iron levels are high, but if iron export from cells is unregulated, iron may accumulate in the eye and degrade the macula. Iron is a necessary mineral for many of the bodys functions, including vision. This means that ferritin is constantly being made no matter whether iron levels are high or low. The answer is that a genetic mutation has turned off the bodys ability to make ferritin in response to changing iron levels.
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